Harper J, Ribeiro SP, Chan CN, Aid M, Deleage C, Micci L, Pino M, Cervasi B, Raghunathan G, Rimmer E, Ayanoglu G, Wu G, Shenvi N, Barnard RJ, Del Prete GQ, Busman-Sahay K, Silvestri G, Kulpa DA, Bosinger SE, Easley KA, Howell BJ, Gorman D, Hazuda DJ, Estes JD, Sekaly RP, Paiardini M.* Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.*J Clin Invest. 2022 Apr 15;132(8):e155251. doi: 10.1172/JCI155251. PMID: 35230978; PMCID: PMC9012284.

Pino M, Pereira Ribeiro S, Pagliuzza A, Ghneim K, Khan A, Ryan E, Harper JL, King CT, Welbourn S, Micci L, Aldrete S, Delman KA, Stuart T, Lowe M, Brenchley JM, Derdeyn CA, Easley K, Sekaly RP, Chomont N, Paiardini M, Marconi VC. *Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.* PLoS Pathog. 2021 Aug 27;17(8):e1009825. doi: 10.1371/journal.ppat.1009825. PMID: 34449812; PMCID: PMC8397407. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP.* A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.* Sci Immunol. 2021 Jul 15;6(61):eabh3634. doi: 10.1126/sciimmunol.abh3634. PMID: 34266981; PMCID: PMC9119307. Lee MY, Upadhyay AA, Walum H, Chan CN, Dawoud RA, Grech C, Harper JL, Karunakaran KA, Nelson SA, Mahar EA, Goss KL, Carnathan DG, Cervasi B, Gill K, Tharp GK, Wonderlich ER, Velu V, Barratt-Boyes SM, Paiardini M, Silvestri G, Estes JD, Bosinger SE.* Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.* PLoS Pathog. 2021 Jun 28;17(6):e1009674. doi: 10.1371/journal.ppat.1009674. PMID: 34181694; PMCID: PMC8270445. Harper J, Huot N, Micci L, Tharp G, King C, Rascle P, Shenvi N, Wang H, Galardi C, Upadhyay AA, Villinger F, Lifson J, Silvestri G, Easley K, Jacquelin B, Bosinger S, Müller-Trutwin M, Paiardini M.* IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques.* Nat Commun. 2021 May 17;12(1):2866. doi: 10.1038/s41467-021-23189-7. PMID: 34001890; PMCID: PMC8129202. Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M.* SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.*Nat Commun. 2021 Feb 24;12(1):1282. doi: 10.1038/s41467-021-21402-1. PMID: 33627642; PMCID: PMC7904927.

Hoang TN, Pino M, Boddapati AK, Viox EG, Starke CE, Upadhyay AA, Gumber S, Nekorchuk M, Busman-Sahay K, Strongin Z, Harper JL, Tharp GK, Pellegrini KL, Kirejczyk S, Zandi K, Tao S, Horton TR, Beagle EN, Mahar EA, Lee MYH, Cohen J, Jean SM, Wood JS, Connor-Stroud F, Stammen RL, Delmas OM, Wang S, Cooney KA, Sayegh MN, Wang L, Filev PD, Weiskopf D, Silvestri G, Waggoner J, Piantadosi A, Kasturi SP, Al-Shakhshir H, Ribeiro SP, Sekaly RP, Levit RD, Estes JD, Vanderford TH, Schinazi RF, Bosinger SE, Paiardini M.* Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.* Cell. 2021 Jan 21;184(2):460-475.e21. doi: 10.1016/j.cell.2020.11.007. Epub 2020 Nov 10. PMID: 33278358; PMCID: PMC7654323. Pino M, Uppada SB, Pandey K, King C, Nguyen K, Shim I, Rogers K, Villinger F, Paiardini M, Byrareddy SN.* Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques.* Front Immunol. 2020 Jul 17;11:1275. doi: 10.3389/fimmu.2020.01275. PMID: 32765488; PMCID: PMC7379916. Strongin Z, Micci L, Fromentin R, Harper J, McBrien J, Ryan E, Shenvi N, Easley K, Chomont N, Silvestri G, Paiardini M.* Virologic and Immunologic Features of Simian Immunodeficiency Virus Control Post-ART Interruption in Rhesus Macaques.* J Virol. 2020 Jul 1;94(14):e00338-20. doi: 10.1128/JVI.00338-20. PMID: 32350073; PMCID: PMC7343203. Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ; BEAT-HIV Delaney Collaboratory to Cure HIV-1 infection.* Recommendations for measuring HIV reservoir size in cure-directed clinical trials.* Nat Med. 2020 Sep;26(9):1339-1350. doi: 10.1038/s41591-020-1022-1. Epub 2020 Sep 7. PMID: 32895573; PMCID: PMC7703694. Paiardini M, Dhodapkar K, Harper J, Deeks SG, Ahmed R.* Editorial: HIV and Cancer Immunotherapy: Similar Challenges and Converging Approaches.* Front Immunol. 2020 Mar 31;11:519. doi: 10.3389/fimmu.2020.00519. PMID: 32296432; PMCID: PMC7138010. Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini M.* CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption.* Nat Med. 2020 Apr;26(4):519-528. doi: 10.1038/s41591-020-0782-y. Epub 2020 Mar 16. PMID: 32284611; PMCID: PMC7790171. Aldrete S, Jang JH, Easley KA, Okulicz J, Dai T, Chen YN, Pino M, Agan BK, Maves RC, Paiardini M, Marconi VC.* CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy.*PLoS One. 2020 Jan 6;15(1):e0227124. doi: 10.1371/journal.pone.0227124. PMID: 31905222; PMCID: PMC6944336.

Pino M, Paganini S, Deleage C, Padhan K, Harper JL, King CT, Micci L, Cervasi B, Mudd JC, Gill KP, Jean SM, Easley K, Silvestri G, Estes JD, Petrovas C, Lederman MM, Paiardini M.* Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.* PLoS Pathog. 2019 Oct 18;15(10):e1008081. doi: 10.1371/journal.ppat.1008081. PMID: 31626660; PMCID: PMC6834281. Hoang TN, Paiardini M.* Role of cytokine agonists and immune checkpoint inhibitors toward HIV remission.*Curr Opin HIV AIDS. 2019 Mar;14(2):121-128. doi: 10.1097/COH.0000000000000528. PMID: 30585798; PMCID: PMC6469389.

Hoang TN, Harper JL, Pino M, Wang H, Micci L, King CT, McGary CS, McBrien JB, Cervasi B, Silvestri G, Paiardini M.* Bone Marrow-Derived CD4+ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir.* J Virol. 2018 Dec 10;93(1):e01344-18. doi: 10.1128/JVI.01344-18. PMID: 30305357; PMCID: PMC6288341. Pino M, Paiardini M, Marconi VC.* Progress in achieving long-term HIV remission.* Curr Opin HIV AIDS. 2018 Sep;13(5):435-445. doi: 10.1097/COH.0000000000000487. PMID: 29889662; PMCID: PMC8696266. Huot N, Bosinger SE, Paiardini M, Reeves RK, Müller-Trutwin M.* Lymph Node Cellular and Viral Dynamics in Natural Hosts and Impact for HIV Cure Strategies.* Front Immunol. 2018 Apr 19;9:780. doi: 10.3389/fimmu.2018.00780. PMID: 29725327; PMCID: PMC5916971. Abdel-Mohsen M, Kuri-Cervantes L, Grau-Exposito J, Spivak AM, Nell RA, Tomescu C, Vadrevu SK, Giron LB, Serra-Peinado C, Genescà M, Castellví J, Wu G, Del Rio Estrada PM, González-Navarro M, Lynn K, King CT, Vemula S, Cox K, Wan Y, Li Q, Mounzer K, Kostman J, Frank I, Paiardini M, Hazuda D, Reyes-Terán G, Richman D, Howell B, Tebas P, Martinez-Picado J, Planelles V, Buzon MJ, Betts MR, Montaner LJ.* CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.* Sci Transl Med. 2018 Apr 18;10(437):eaar6759. doi: 10.1126/scitranslmed.aar6759. PMID: 29669853; PMCID: PMC6282755.

Cartwright EK, Spicer L, Smith SA, Lee D, Fast R, Paganini S, Lawson BO, Nega M, Easley K, Schmitz JE, Bosinger SE, Paiardini M, Chahroudi A, Vanderford TH, Estes JD, Lifson JD, Derdeyn CA, Silvestri G.* CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.* Immunity. 2016 Sep 20;45(3):656-668. doi: 10.1016/j.immuni.2016.08.018. PMID: 27653601; PMCID: PMC5087330. Micci L, Paiardini M.* Editorial overview: Animal models for viral diseases.* Curr Opin Virol. 2016 Aug;19:ix-xi. doi: 10.1016/j.coviro.2016.08.014. PMID: 27619791. Paiardini M, Lichterfeld M.*Follicular T helper cells: hotspots for HIV-1 persistence.*Nat Med. 2016 Jul 7;22(7):711-2. doi: 10.1038/nm.4138. PMID: 27387885. Calascibetta F, Micci L, Carnathan D, Lawson B, Vanderford TH, Bosinger SE, Easley K, Chahroudi A, Mackel J, Keele BF, Long S, Lifson J, Paiardini M, Silvestri G.*Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis.*J Virol. 2016 Jul 27;90(16):7541-7551. doi: 10.1128/JVI.00598-16. PMID: 27279614; PMCID: PMC4984638. Ryan ES, Micci L, Fromentin R, Paganini S, McGary CS, Easley K, Chomont N, Paiardini M.*Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.*PLoS Pathog. 2016 Feb 1;12(2):e1005412. doi: 10.1371/journal.ppat.1005412. PMID: 26829644; PMCID: PMC4735119.

McGary CS, Deleage C, Harper J, Micci L, Ribeiro SP, Paganini S, Kuri-Cervantes L, Benne C, Ryan ES, Balderas R, Jean S, Easley K, Marconi V, Silvestri G, Estes JD, Sekaly RP, Paiardini M.* CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.* Immunity. 2017 Oct 17;47(4):776-788.e5. doi: 10.1016/j.immuni.2017.09.018. PMID: 29045906; PMCID: PMC5679306. McGary CS, Alvarez X, Harrington S, Cervasi B, Ryan ES, Iriele RI, Paganini S, Harper JL, Easley K, Silvestri G, Ansari AA, Lichterfeld M, Micci L, Paiardini M.* The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques.*Mucosal Immunol. 2017 Jul;10(4):1082-1096. doi: 10.1038/mi.2016.116. Epub 2017 Jan 4. PMID: 28051083; PMCID: PMC5474141.

Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M.*Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.*J Clin Invest. 2015 Dec;125(12):4497-513. doi: 10.1172/JCI81400. Epub 2015 Nov 9. PMID: 26551680; PMCID: PMC4665780. Micci L, McGary CS, Paiardini M.*Animal models in HIV cure research.*J Virus Erad. 2015 Jan 1;1(1):17-22. PMID: 27482392; PMCID: PMC4946666.

Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, Estes JD, Silvestri G, Lackner AA, Paiardini M.*CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.*PLoS Pathog. 2014 Oct 30;10(10):e1004467. doi: 10.1371/journal.ppat.1004467. PMID: 25356757; PMCID: PMC4214815. d'Ettorre G, Baroncelli S, Micci L, Ceccarelli G, Andreotti M, Sharma P, Fanello G, Fiocca F, Cavallari EN, Giustini N, Mallano A, Galluzzo CM, Vella S, Mastroianni CM, Silvestri G, Paiardini M, Vullo V.*Reconstitution of intestinal CD4 and Th17 T cells in antiretroviral therapy suppressed HIV-infected subjects: implication for residual immune activation from the results of a clinical trial.*PLoS One. 2014 Oct 23;9(10):e109791. doi: 10.1371/journal.pone.0109791. PMID: 25340778; PMCID: PMC4207675. McGary CS, Silvestri G, Paiardini M.*Animal models for viral infection and cell exhaustion.*Curr Opin HIV AIDS. 2014 Sep;9(5):492-9. doi: 10.1097/COH.0000000000000093. PMID: 25023622; PMCID: PMC4180228. Cartwright EK, McGary CS, Cervasi B, Micci L, Lawson B, Elliott ST, Collman RG, Bosinger SE, Paiardini M, Vanderford TH, Chahroudi A, Silvestri G.*Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections.*J Immunol. 2014 May 15;192(10):4666-73. doi: 10.4049/jimmunol.1303193. Epub 2014 Apr 11. PMID: 24729621; PMCID: PMC4011949. McGary CS, Cervasi B, Chahroudi A, Micci L, Taaffe J, Meeker T, Silvestri G, Davenport MP, Paiardini M.*Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques.*J Virol. 2014 Apr;88(8):4533-42. doi: 10.1128/JVI.03515-13. Epub 2014 Feb 5. PMID: 24501416; PMCID: PMC3993768.

Pallikkuth S, Micci L, Ende ZS, Iriele RI, Cervasi B, Lawson B, McGary CS, Rogers KA, Else JG, Silvestri G, Easley K, Estes JD, Villinger F, Pahwa S, Paiardini M.*Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.*PLoS Pathog. 2013;9(7):e1003471. doi: 10.1371/journal.ppat.1003471. Epub 2013 Jul 4. PMID: 23853592; PMCID: PMC3701718. Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL.*Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.*PLoS Pathog. 2013;9(6):e1003441. doi: 10.1371/journal.ppat.1003441. Epub 2013 Jun 27. PMID: 23825945; PMCID: PMC3694849. Cervasi B, Carnathan DG, Sheehan KM, Micci L, Paiardini M, Kurupati R, Tuyishime S, Zhou XY, Else JG, Ratcliffe SJ, Ertl HC, Silvestri G.*Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing the simian immunodeficiency virus Gag/Tat fusion protein and challenged intrarectally with repeated low doses of SIVmac.*J Virol. 2013 Sep;87(17):9420-30. doi: 10.1128/JVI.01456-13. Epub 2013 Jun 26. PMID: 23804645; PMCID: PMC3754116. Paiardini M, Müller-Trutwin M.*HIV-associated chronic immune activation.*Immunol Rev. 2013 Jul;254(1):78-101. doi: 10.1111/imr.12079. PMID: 23772616; PMCID: PMC3729961.

Micci L, Cervasi B, Ende ZS, Iriele RI, Reyes-Aviles E, Vinton C, Else J, Silvestri G, Ansari AA, Villinger F, Pahwa S, Estes JD, Brenchley JM, Paiardini M.*Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques.*Blood. 2012 Nov 8;120(19):3925-35. doi: 10.1182/blood-2012-04-420240. Epub 2012 Sep 18. PMID: 22990011; PMCID: PMC3496953.